David Friedberg sits at the intersection of deep tech, public markets, and practical operating experience, and his SPAC is a useful lens for where bio-industrial is headed.
I wrote this guide to demystify TPB Acquisition Corporation I, unpack what the Lavoro deal signals, and give founders, investors, and CFOs a tactical playbook for the next wave of bio-industrial opportunities.
I keep it direct, I keep it practical, and I call out what matters for execution, fundraising, and timing.

David Friedberg is the founder of The Production Board, an operator-led investment company focused on agriculture, biology, climate, and computation.
He built his reputation by shipping in hard markets and translating deep tech into revenue, not just research.
That makes his SPAC, TPB Acquisition Corporation I, a meaningful case study for bio-industrial strategy.
I care about this because voice and incentive alignment matter in public markets.
A sponsor with operating chops frames risk differently, pushes for cash-generative paths, and avoids vanity science.
TPB Acquisition Corporation I is a blank-check company sponsored by The Production Board to merge with a business and take it public through a de-SPAC.
The ticker before merger was TPBA, and it targeted agriculture, bio-industrial, and adjacent categories where operational advantage compounds.
A SPAC is a financing vehicle with a clock, a promote, and a mandate.
It lives or dies by match quality between target and market appetite.
That matching is exactly where the insight lives for founders and investors in deep tech today.
TPB Acquisition Corporation I chose Lavoro, a Latin American agricultural inputs retailer, because the business throws off cash and sits at the nerve center of the farm economy.
The trade was simple and smart.
Pick distribution in a massive category with recurring demand, diversified SKUs, and pricing power, rather than pre-revenue bio manufacturing hype.
This was not a lab story.
It was a distribution moat story with upside from bio-based inputs as the product mix evolves.
The Lavoro choice signals that public investors want bio-industrial exposure without scale-up risk.
It says distribution plus data beats hero chemistry when capital is scarce.
It also says platform positioning matters more than a single molecule.
In other words, put the cash register first and let the product roadmap ride shotgun.
I tell founders to map their business to this risk curve and remove as much process risk as possible pre-listing.
Every SPAC has three levers founders should understand before they even consider that path.
The sponsor promote, the warrant mechanics, and the PIPE fill.
These define dilution, redemption risk, and whether you actually raise the cash you think you will.
If you cannot line up a strong PIPE with aligned long-only investors, the math can get ugly fast.
For more on investor readiness, see our blog post: The AI Data Room for Fundraising.
Timing is a feature, not a bug, in public markets.
The SPAC boom of 2020 and 2021 pulled forward listings, but the bust of 2022 and 2023 reset the bar.
When rates rise and risk appetite falls, de-SPACs that survive are cash-generative or have project-level finance behind them.
That is why a bio-industrial distribution business cleared the bar while pre-revenue synbio names struggled.
Your milestone plan must match the window you target, not the window you wish existed.
For more market context, see our blog post: SPACs After the Boom: What Still Works in 2025.
High redemption rates are the headline risk in modern SPACs.
When 80 to 90 percent of IPO buyers take their cash back, your trust proceeds vanish and your PIPE must backfill.
The lesson is blunt.
Treat the trust as optional and build your deal to work on the PIPE alone.
Investors will pay for recurring revenue with defensible margin and working capital discipline.
They will discount grand TAM decks that lack unit economics and conversion proof.
In bio-industrial, this means contracted offtakes, hedged inputs, and realistic COGS ramp matter more than blue-sky molecule maps.
I advise founders to publish revenue quality metrics in their data rooms and to cut vanity slides.
For a practical framework, see our blog post: Revenue Quality Over Vanity Metrics.
Discovery gets headlines.
Distribution gets cash flow.
TPB Acquisition Corporation I selected a target with control of shelves and relationships, not just IP.
That choice shows a bias to own the channel so you can shape the product mix over time.
If you can bundle bio-based inputs through a trusted distributor, you compress sales cycles and lift margins without CapEx shock.
Fermentation and catalysis look elegant on a whiteboard and messy in steel.
Scale-up takes longer, costs more, and often suffers from yield drift, contamination, and energy surprises.
Public investors now price this reality into valuations.
If your plan depends on greenfield builds, show a path with tolling, debottlenecking, and modular trains before you propose a mega-plant.
For a belt-and-suspenders plan, present a three-stage scale curve and a contingency budget.
The funding stack for bio-industrial has evolved, and founders who learn it win.
I now see hybrid structures that blend equity, project finance, tax credits, and loan guarantees.
Done right, this lowers WACC and reduces dilution while de-risking scale-up.
For a founder’s walkthrough, see our blog post: Venture Debt vs Project Finance: A Founder’s Guide.
For policy mechanics, see our blog post: IRA Cheatsheet for Climate Founders.
Offtakes make or break a biomanufacturing raise.
The details decide whether lenders and public investors believe your model.
You need tenor, volume, price floors, indexed adjustments, take-or-pay, and credible counterparties.
Then you layer hedges for energy, feedstock, and FX if you are cross-border.
Do not outsource this to legal alone.
Own it as a core GTM motion.
For negotiation tactics, see our blog post: How to Negotiate Bankable Offtakes.
The post-boom scoreboard in synthetic biology is sobering and useful.
Ginkgo Bioworks pivoted to a platform and services model and is rebuilding credibility on program wins and cash runway.
Zymergen and Amyris showed that premium consumer and platform dreams cannot outrun scale-up and demand risk forever.
The takeaway is not that synbio fails.
The takeaway is that product market fit and capital discipline must lead the dance.
TPB Acquisition Corporation I’s Lavoro deal fit that calculus with distribution first and bio-based pull-through second.
Public investors want boring excellence.
They want contracted revenue, clear cash conversion cycles, and catalysts that show up on time.
They want less science fiction and more delivery.
If you can tie each quarterly catalyst to a bankable metric, you will stand out.
If you want to be de-SPAC-able, build for auditability and predictability.
Start with GAAP discipline, SOX readiness, and repeatable forecasting.
Then design your investor relations calendar before you even announce the deal.
For templates and workflows, see our blog post: First-Time Deep Tech CFO Playbook.
In bio manufacturing, the technical KPIs and the financial KPIs rhyme.
Titer, rate, and yield map straight to COGS, throughput, and gross margin.
Show the translation and you earn trust.
For a deeper dive, see our blog post: Titer, Rate, Yield: The Metrics That Matter.
Good narrative is a strategy, not a slide.
Public investors need a clean through-line from today’s cash flows to tomorrow’s upside.
Your story should be simple enough to repeat and specific enough to model.
I build it with four beats.
For narrative frameworks, see our blog post: Narrative Market Fit.
The Production Board is more than a sponsor.
It is an incubator, investor, and operator that builds and scales companies across ag, bio-industrial, and climate.
That platform creates advantages in diligence, recruiting, and post-merger execution.
It also helps a public company plug into a network of suppliers, customers, and technical advisors on day one.
I look for this ecosystem edge when I evaluate any deep tech listing.
Here is the short list I share when someone asks if they are ready for the public spotlight.
For data room checklists, see our blog post: The AI Data Room for Fundraising.
For planning your model, see our blog post: The 18-Tab Financial Model That Won Our Last Round.
I do not expect a return to the 2021 SPAC frenzy.
I do expect targeted de-SPACs where sponsors bring operator DNA and choose cash-generative targets.
I also expect more hybrid IPOs with cornerstone investors and more private credit backing project-level assets.
If you build with that mix in mind, you will have more options when the window opens.
Deep tech fails when milestones are fuzzy and capital calls are lumpy.
I plan milestones as bite-size proofs that unlock the next tranche at a higher price.
Each milestone must kill a risk, show a metric moved, and de-risk the next phase.
For a field-tested approach, see our blog post: Milestone-Based Financing for Deep Tech.
Do not cherry-pick glamour comps.
Study boring winners with cash flow, durable margins, and disciplined capital allocation.
In ag and bio-industrial, that means looking at distributors, ingredient platforms, and process tech companies with real EBITDA.
Map their gross margin bridges and capital intensity, and then backsolve your own plan.
Lavoro was a bet on Latin American agriculture and the resilience of regional supply chains.
Your geography can be a moat if it aligns feedstock access, logistics costs, and policy incentives.
Place capacity near cheap energy, stable ports, and supportive regulators, and the model starts to click.
Place it wrong, and even a great organism will lose to freight and power bills.
The quiet secret in a smooth de-SPAC is a disciplined investor CRM.
You need a pipeline of long-onlys, crossover funds, and strategics who understand your space months in advance.
You also need to track every question and close the loop with hard data.
For workflows and templates, see our blog post: Build an Investor CRM That Actually Works.
Going public is a lifestyle decision as much as a financing decision.
You will live on a calendar of earnings, guidance, and conferences.
If you thrive on cadence and accountability, you will like it.
If you prefer long, quiet build cycles, stay private longer and use project finance to scale.
Generative AI makes diligence faster and sharper, and that cuts both ways.
Investors will synthesize your filings, patents, supplier checks, and social proof in minutes, not weeks.
If your narrative is inconsistent, the gap will show.
Use AI to preflight your own materials and pressure-test every claim before you go live.
It is a SPAC sponsored by The Production Board to merge with an operating company and take it public.
He brings operator discipline and a systems view, which usually translates into better target selection and post-merger execution.
Because Lavoro has cash flow, distribution advantages, and exposure to bio-based inputs without the heavy scale-up risk.
Yes, but only for businesses with contracted revenue, clear margins, and realistic guidance backed by strong PIPE investors.
High redemptions reduce cash from the trust, making the PIPE essential to fund the business plan.
Contracted backlog, gross margin trajectory, cash conversion, and clear operating leverage.
Build audit-ready systems, design a KPI set you can report every quarter, and pre-wire anchor investors for the PIPE.
They anchor revenue, support project finance, and lower perceived risk for both lenders and public investors.
It adds valuable tax credits and incentives that improve project economics and make debt more accessible.
Both matter, but distribution-first models are de-risked and usually preferred by public markets right now.
TPB Acquisition Corporation I shows how an operator-led SPAC can pick resilient cash flow over speculative science and still deliver exposure to bio-industrial upside.
If you are building in deep tech, take the hint and anchor your plan on distribution moats, contracted revenue, and a financing stack that reduces dilution.
Use offtakes, hedges, and policy incentives to make your economics bankable, and keep your story tight, testable, and on time.
That is how you meet the public markets on your terms and avoid the traps that caught the first synbio wave.
This is the practical playbook I take from David Friedberg and TPB Acquisition Corporation I, and it is the lens I use for bio-industrial opportunities at Capitaly.vc.
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